Omer Cell cover
2022
Attya Omer
Academia
Illustration
Journal cover
Cell cover artwork
We were commissioned to design the cover artwork for Cell (Volume 185, Issue 13), to illustrate the work of Omer-Javed et al.. Omer-Javed and Colleagues utilised the method of mobilisation to insert corrected blood stem cells into the depleted niche, without the need for toxic conditioning regimens.
Mobilisation in gene therapy
In gene therapy, mobilisation refers to when damaged cells (yellow) leave the bone marrow and enter the bloodstream (top left) with the help of 'mobilisers'. After the infusion of gene therapy, the objective is for cells carrying the functional gene (green) to migrate into the now-depleted bone marrow and over time, generate new blood cells with the functional gene (bottom right). Usually, chemotherapy is required to remove these damaged cells.